Book Review | New Books December 2003
نویسنده
چکیده
A. " TSG loss " model in human tumors would imply functional of physical elimination of both tumor suppressor alleles. Therefore deletion would be effective if it would eliminate one allele of the gene leading to LOH in majority of tumors. B. In aneuploid human tumors the " Mandatory chromosomal segment copy number " model considers that a tumor suppressor gene copy number gain having chance to occur with numerical chr3 changes would have to be diminished by deletion of the 3p14-p21 region, not necessarily accompanied by LOH and tendency to keep 3q gain. In order to test applicability of these models, we have studied FER status in several RCC cell lines. Preliminarily we performed metaphase chromosome analysis using FISH with chr3 centromere specific probe and 10 FER specific probes. Based on this analysis we have selected 7 cell lines that had FER deletions. We considered the FER region deleted, when derivative chr3 (rearranged chromosome that has centromere from chr3) did not have FER FISH signals and FER signals were not present on chr3 translocation to other chromosomes. We analysed these 7 cell lines for retention of heterozygosity using eight 3p14.3-p21.2 (FER) microsatellite markers (see table below). Four out of seven cell lines retained heterozygosity of several FER polymorphic markers. Taking in account that in all these lines the deletion spanned the entire FER (all FER FISH markers were absent from the derivative chromosomes) we concluded that the copy number loss of FER was not accompanied by LOH in these 4 cell lines. This supported the " Mandatory chromosomal segment copy number " model.
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of no more than 150 words. The names of the authors should only appear on the title page. Style should follow American Psychological Association (APA) (Fifth Edition) guidelines. BOOK REVIEWS: Books for review and book review manuscripts should be sent to Book Review Editor, at the ad-
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ورودعنوان ژورنال:
- Environmental Health Perspectives
دوره 111 شماره
صفحات -
تاریخ انتشار 2003